Your website design should represent the majority of users, that means, always make bigger what it’s important for your target customers. Use at least 90 % of the homepage real estate to give information to your biggest user group.

"Let the smallest group of visitors investigate by themselves…"

Specially the homepage should contemplate this rule. Let the smallest group of visitors investigate by themselves and look for the information they need.

For example HP makes the "Home & Home Office" section bigger than others. Doing this they improve the user experience of the biggest customer group.

3M places the links for job applicants and investors at the bottom of the homepage. It’s not that they are not important, it’s that they represent a small group of users.